Testosterone plays a significant role in men’s cardiovascular and metabolic health. There has been much research done on its potential cardioprotective effects, the influence of testosterone on diabetes management, and its impact on weight loss—we’ve put together a quick summary on the latest evidence.
Is testosterone therapy bad for your heart?
You may have heard concerns about testosterone therapy and cardiovascular risks. Let’s clear that up. While two recent studies raised questions about potential risks, they had serious flaws, including poor study design and limited data.
In fact, when you look at the bigger picture, the evidence overwhelmingly supports the benefits of maintaining healthy testosterone levels for cardiovascular health.
Cardioprotective Effects of Testosterone
Research shows that men with normal testosterone levels tend to have lower risks of coronary artery disease and better overall heart health. Testosterone therapy has been linked to reductions in obesity, fat mass, and waist circumference, along with improvements in blood sugar control. Several large studies and randomized trials even show improved heart function in men with coronary artery disease or heart failure who received testosterone compared to those who didn’t.
The largest meta-analysis to date found no increase in cardiovascular risks with testosterone therapy and even suggested reduced risks in men with metabolic conditions.
So is testosterone therapy bad for your heart?
There’s no solid evidence that testosterone therapy increases cardiovascular risk, and in fact, it may provide significant benefits for heart health when used appropriately.
Additionally, a systematic review in Mayo Clinic Proceedings found that testosterone therapy reduced total cholesterol by approximately 16 mg/dL (0.41 mmol/L) and had a small reduction in HDL cholesterol by around 2 mg/dL (0.05 mmol/L). These effects on lipid profiles suggest potential cardiovascular benefits when testosterone therapy is managed carefully. (Mayo Clinic Proceedings)
Testosterone and Diabetes Protection
Testosterone also plays a key role in metabolic health. Studies show that a significant proportion of men with type 2 diabetes have low testosterone levels. For example, the Journal of Clinical Endocrinology & Metabolism found that 43% of men with diabetes had reduced testosterone, which was independently associated with insulin resistance. (Oxford Academic)
The TRAVERSE randomized trial, published in JAMA Internal Medicine, demonstrated that testosterone therapy reduced the progression of prediabetes to diabetes in men with low testosterone. It also improved insulin sensitivity and glycemic control, contributing to better metabolic outcomes. (JAMA Internal Medicine)
Testosterone and Weight Loss
Weight loss is another area where testosterone therapy shows promise. Long-term testosterone treatment has been associated with sustained reductions in fat mass and waist circumference. A study in the International Journal of Obesity found that men receiving testosterone injections experienced significant weight loss over 11 years. (International Journal of Obesity)
Similarly, a randomized trial in BMC Medicine reported that testosterone treatment, combined with a reduced-calorie diet, led to greater fat loss compared to diet alone. These findings highlight how testosterone therapy can complement lifestyle changes to support weight management. (BMC Medicine)
The Bottom Line
Testosterone therapy, when used appropriately, is not just about addressing symptoms of low testosterone—it’s about improving overall health and quality of life.
While concerns about testosterone therapy and cardiovascular risks have been raised, the broader body of research tells a different story. Maintaining healthy testosterone levels appears to support cardiovascular health, improve metabolic function, and aid in weight loss, among a long list of other benefits.
As with any medical treatment, personalized medical advice and careful monitoring remain essential to ensure safe and effective treatment. It’s all about a personalized approach—something we pride ourselves in here at Blue Sky MD. We understanding that what works for one person may not work for someone else, given the complexity of hormones and health in general.
If you’re curious about hormone therapy for men, or experiencing symptoms of low testosterone like low libido, trouble sleeping, weight gain, lack of clarity, or more, it’s a good idea to get your T levels checked. Schedule your first appointment with us to get your labs started today.
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Dr. David LaMond, MD
Founder, Medical Director, Blue Sky MD
Dr. LaMond is a nutrition and prevention expert; who is a successful medical entrepreneur. Dave developed and operates numerous successful medical practices, along with a consulting company which helps physicians and medical practitioners operate successful independent practices. Drawing from his foundation and board certification in Family Medicine, he developed the innovative medical principles behind the Blue Sky MD concept of total patient care. Blue Sky MD has appeared on the INC 5000 list three times; as one of the 5000 fastest growing privately held companies in the US.
Dave has been a featured speaker for numerous medical conferences and has been a business and health consultant and has made several appearances on health television broadcasts. His written work has been featured in medical journals and other print media; with a focus on sports medicine, nutrition, wellness and non-invasive cosmetic procedures.
Additionally, Dr. LaMond has been a luminary, speaker and consultant for Crescent Health Solutions, Eleme Medical, Osyris, Suneva Medical and Candela Corporations, served as a clinical professor for Wake Forest University and is an expert in non-invasive and minimally invasive body contouring and cosmetic laser surgery.
Dr LaMond is passionate about the outdoors and has a love for mountain biking. He works as a nutritional coach and physician for professional cyclists, and enjoys training and riding along-side them. Dave has competed in high level mountain bike events regionally and nationally in masters level competition and has been on the podium at USA cycling National Championships.
